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Drinking blushers should not take three types of drugs
People who drink blush easily should take three types of drugs, nitroglycerin, antibiotics and diuretics when taking the medicine. After taking any of these three types of drugs, the alcohol is catalyzed into acetaldehyde and thenFurther decomposition by the action of acetaldehyde dehydrogenase 2.
If the activity of this enzyme is problematic, acetaldehyde cannot be metabolized in time, causing harm to the body.
銆€銆€Many people drink red blush, the main culprit in drinking blush is not alcohol (ethanol), but acetaldehyde.
In the body, alcohol is first catalyzed to acetaldehyde and then further decomposed by the action of acetaldehyde dehydrogenase 2.
If the activity of this enzyme is a problem, acetaldehyde can not be metabolized in time, and a large amount of it stays in the body, which may relax the facial blood vessels, causing blushing. In severe cases, it may cause damage to the heart, brain, liver, kidney and other organs.
銆€銆€People who drink blush easily should be cautious when taking the medicine, especially pay attention to the following three types of medicine.
銆€銆€1.
Nitroglycerin free radicals, if not treated in time, may cause acute myocardial infarction, or even sudden death due to severe arrhythmia.
Nitroglycerin is a “life-saving drug” for the treatment of angina pectoris, but many people who drink alcohol easily blush, after taking these drugs, acetaldehyde dehydrogenase 2 can metabolize nitroglycerin, produce nitric oxide, achieve vasodilation, relieve angina.
The activity of acetaldehyde dehydrogenase 2 in drinking blush is not high, and the effect of taking nitroglycerin may be bad or even ineffective.
It is recommended that these patients use nitroglycerin cautiously, and if necessary, supplement or change the nitrates, beta blockers, calcium channel blockers or quick-acting rescue pills, and the Chinese herbal preparations such as Shexiang Baoxin Pill to prevent unreasonable use of drugs.Delay in treatment, bring life-threatening risks.
銆€銆€2.
Antibiotics should be used cautiously within the contraction of antibiotics after drinking.
The combination of antibiotics and acetaldehyde dehydrogenase 2 inhibits the activity of the enzyme, so that acetaldehyde can not be metabolized in time, accumulates in the body, and the disulfiram reaction occurs. The clinical manifestations are skin fever, facial redness, head vascular pulsation or pulsation.Headache, severe cases can cause difficulty breathing, nausea and vomiting, sweating dry mouth, chest pain, rapid heartbeat, blood pressure drop and even shock.
Drugs that cause disulfiram reactions are: metronidazole, ketoconazole, chloramphenicol and certain cephalosporin antibiotics.
銆€銆€3.
Diuretic ethanol and its metabolite acetaldehyde expand blood vessels and enhance the efficacy of vasodilators.
Especially when using diuretic antihypertensive drugs such as thiazides, if drinking alcohol, it can aggravate orthostatic hypotension.
People who drink blush have a poor ability to metabolize acetaldehyde and are more likely to be at risk, so avoid drinking alcohol when taking certain drugs.